Synthesis and anticancer evaluation of bis(benzimidazoles), bis(benzoxazoles), and benzothiazoles

被引：353

作者：

Huang, Shu-Ting

Hsei, I-Jen

Chen, Chinpiao ^{[1
]}

机构：

[1] Natl Dong Hwa Univ, Dept Chem, Hualien 974, Taiwan

[2] Tzu Chi Univ, Coll Med, Dept Med Lab Sci & Biotechnol, Hualien 970, Taiwan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 17期

关键词：

bis(benzoxazole); benzothiazole; anti-cancer; cytotoxicity;

D O I：

10.1016/j.bmc.2006.05.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four classes of UK-1 analogues were synthesized and their cytotoxicity testing against human A-549, BFTC-905, RD, MES-SA, and HeLa carcinoma cell lines was determined. The results revealed that UK-1 and four of these analogues (15-18) are potent against the cancer cell lines. In particular, compound 16 is more potent than UK-1 against A-549 and HeLa cell lines, and compounds 15, 17, and 18 selectively exhibit potent cytotoxic activity against the BFTV-905 cells (IC50 9.6 PM), A-549 cells (IC50 6.6 mu M), and MES-SA cells (IC50 9.2 mu M),respectively. (c) 2006 Elsevier Ltd. All rights reserved.

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页码：6106 / 6119

页数：14

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