Dystroglycan complex in cancer

被引：50

作者：

Brennan, PA ^{[1
]}

Jing, J

Ethunandan, M

Górecki, D

机构：

[1] Queen Alexandra Hosp, Maxillofacial Unit, Dept Head & Neck Surg, Portsmouth PO6 3LY, Hants, England

[2] Inst Biomed & Biomol Sci, Sch Pharm & Biomed Sci, Mol Med Grp, Portsmouth, Hants, England

来源：

EJSO | 2004年 / 30卷 / 06期

关键词：

dystroglycan; cancer; adhesion; metastasis; review;

D O I：

10.1016/j.ejso.2004.03.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Abnormalities in the interactions between tumour cells, adhesion molecules and extracellular matrix proteins are often implicated in the behaviour of carcinoma cells. The alpha- and beta-dystroglycan (DG) proteins form part of the large dystrophin-associated protein (DAP) complex. They are involved in epithelial. cell. development, formation of the basement membrane and maintenance of tissue integrity. Specific changes and reduction or toss of DG expression have been reported in human breast, colon, head and neck, and prostate cancers, implicating it in tumour invasion and dissemination. Degradation of beta-DG by matrix metalloproteinase (MMP) enzymes may assist tumour dissemination. We report the present knowledge of the DG interactions in solid tumour biology. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：589 / 592

页数：4

共 27 条

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