Nicotinic acetylcholine receptor knockout mice as animal models for studying receptor function

被引:43
作者
Marubio, LM [1 ]
Changeux, JP [1 ]
机构
[1] Inst Pasteur, CNR, UA Neurobiol Mol D1284, F-75724 Paris 15, France
关键词
nicotinic acetylcholine receptor;
D O I
10.1016/S0014-2999(00)00007-8
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels, which are involved in a wide range of neuronal functions. During the past decade, a large number of nicotinic acetylcholine receptor subunits have been cloned and showed a discreet yet overlapping distribution pattern. Recently, several groups have produced mutant mice lacking specific nicotinic acetylcholine receptor subunits. In this review, we focus on how the study of these knockout mouse models has advanced our understanding of the role individual nicotinic acetylcholine receptor subunits play in the function and composition of endogenous receptors and the diverse pharmacological actions of nicotine in the mammalian nervous system. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:113 / 121
页数:9
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