Update on the Molecular Pathogenesis of Pancreatic Tumors Other than Common Ductal Adenocarcinoma

被引：16

作者：

Antonello, D. ^{[1
]}

Gobbo, S. ^{[1
]}

Corbo, V. ^{[1
]}

Sipos, B. ^{[2
]}

Lemoine, N. R. ^{[3
,4
]}

Scarpa, A. ^{[1
]}

机构：

[1] Univ Verona, Dipartimento Patologia, IT-37134 Verona, Italy

[2] Univ Kiel, Dept Pathol, D-2300 Kiel, Germany

[3] Barts & London Queen Marys Sch Med & Dent, CR UK Clin Ctr, London, England

[4] Barts & London Queen Marys Sch Med & Dent, Inst Canc, London, England

来源：

PANCREATOLOGY | 2009年 / 9卷 / 1-2期

关键词：

Pancreas; Pathogenesis; Tumor; PAPILLARY-MUCINOUS NEOPLASMS; SOLID-PSEUDOPAPILLARY TUMORS; ACINAR-CELL-CARCINOMA; GENE-EXPRESSION PROFILES; CYSTIC NEOPLASMS; ENDOCRINE TUMORS; BETA-CATENIN; K-RAS; IMMUNOHISTOCHEMICAL ANALYSIS; NUCLEAR EXPRESSION;

D O I：

10.1159/000178872

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Purpose: Although ductal adenocarcinoma is the most common and well known pancreatic tumor type, other distinct epithelial neoplasms affecting the pancreas that show different symptoms, biological behaviors and outcomes are becoming more frequently recognized and documented. Pancreatic epithelial tumors may be separated into ductal and nonductal neoplasms. The former group includes pancreatic ductal adenocarcinoma, intraductal papillary-mucinous tumor, mucinous cystic tumor and serous cystic tumor. The latter group includes pancreatic endocrine tumor, pancreatic acinar cell carcinoma, pancreatoblastoma and solid-pseudopapillary tumor. The aim of this review is to summarize recently acquired knowledge regarding the molecular characterization of these uncommon pancreatic epithelial neoplasms. Recent Findings: Molecular studies of uncommon pancreatic epithelial tumors suggest that the different morphological entities are associated with distinct molecular profiles, highlighting the involvement of different molecular pathways leading to the development of each subtype of pancreatic neoplasm. Conclusion: The correct classification of rare pancreatic epithelial tumors and the identification of their characteristic molecular aspects is the fundamental starting point in identifying novel diagnostic molecular tools and new targets for innovative therapeutic strategies. Copyright (C) 2008 S. Karger AG, Basel and IAP

引用

页码：25 / 33

页数：9

共 121 条

[41] Aberrant hypermethylation of tumor suppressor genes in pancreatic endocrine neoplasms [J].

House, MG ;

Herman, JG ;

Guo, MZ ;

Hooker, CM ;

Schulick, RD ;

Lillemoe, KD ;

Cameron, JL ;

Hruban, RH ;

Maitra, A ;

Yeo, CJ .

ANNALS OF SURGERY, 2003, 238 (03) :423-431

[42] Molecular progression of promoter methylation in intraductal papillary mucinous neoplasms (IPMN) of the pancreas [J].

House, MG ;

Guo, MZ ;

Iacobuzio-Donahue, C ;

Herman, JG .

CARCINOGENESIS, 2003, 24 (02) :193-198

[43] Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas - Comparison with conventional ductal adenocarcinomas [J].

Iacobuzio-Donahue, CA ;

Klimstra, DS ;

Adsay, NV ;

Wilentz, RE ;

Argani, P ;

Sohn, TA ;

Yeo, CJ ;

Cameron, JL ;

Kern, SE ;

Hruban, RH .

AMERICAN JOURNAL OF PATHOLOGY, 2000, 157 (03) :755-761

[44] Exclusion of SMAD4 mutation as an early genetic change in human pancreatic ductal tumorigenesis [J].

Inoue, H ;

Furukawa, T ;

Sunamura, M ;

Takeda, K ;

Matsuno, S ;

Horii, A .

GENES CHROMOSOMES & CANCER, 2001, 31 (03) :295-299

[45] Expression of steroidogenic enzymes by luteinizing cells in the ovarian-type stroma of a mucin-producing cystic tumour of the pancreas [J].

Ishiguro, H ;

Kato, K ;

Kishimoto, T ;

Nagai, Y ;

Takahashi, T ;

Sasano, H ;

Ishikura, H .

HISTOPATHOLOGY, 2003, 43 (01) :97-98

[46] KrasG12D and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas [J].

Izeradjene, Kamel ;

Combs, Chelsea ;

Best, Melissa ;

Gopinathan, Aarthi ;

Wagner, Amary ;

Girady, William M. ;

Deng, Chu-Xia ;

Hruban, Ralph H. ;

Adsay, N. Volkan ;

Tuveson, David A. ;

Hingorani, Sunil R. .

CANCER CELL, 2007, 11 (03) :229-243

[47] Immunohistochemical expression of sonic hedgehog in intraductal papillary mucinous tumor of the pancreas [J].

Jang, Kee-Taek ;

Lee, Kyu Taek ;

Lee, Jong Gyun ;

Choi, Seoung Ho ;

Heo, Jin Seok ;

Choi, Dong Wook ;

Ahn, Geunghwan .

APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2007, 15 (03) :294-298

[48]

Ji Yuan, 2006, Chin J Dig Dis, V7, P39, DOI 10.1111/j.1443-9573.2006.00242.x

[49] Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy [J].

Jimenez, RE ;

Warshaw, AL ;

Z'graggen, K ;

Hartwig, W ;

Taylor, DZ ;

Compton, CC ;

Castillo, CFD .

ANNALS OF SURGERY, 1999, 230 (04) :501-509

[50] DNA copy number status is a powerful predictor of poor survival in endocrine pancreatic tumor patients [J].

Jonkers, Y. M. H. ;

Claessen, S. M. H. ;

Perren, A. ;

Schmitt, A. M. ;

Hofland, L. J. ;

de Herder, W. ;

de Krijger, R. R. ;

Verhofstad, A. A. J. ;

Hermus, A. R. ;

Kummer, J. A. ;

Skogseid, B. ;

Volante, M. ;

Voogd, A. C. ;

Ramaekers, F. C. S. ;

Speel, E. J. M. .

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