Structure of the human telomere in K+ solution:: An intramolecular (3+1) G-quadruplex scaffold

被引：704

作者：

Luu, Kim Ngoc

Phan, Anh Tuan ^{[1
]}

Kuryavyi, Vitaly

Lacroix, Laurent

Patel, Dinshaw J.

机构：

[1] Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA

[2] CNRS, UMR 5153, INSERM, UR 565,Museum Natl Hist Nat, F-75231 Paris 05, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 30期

关键词：

D O I：

10.1021/ja062791w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K+ solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na+ solution and in a K+-containing crystal, involves the following: one anti center dot syn center dot syn center dot syn and two syn, anti, anti, anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA.

引用

页码：9963 / 9970

页数：8

共 41 条

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[Anonymous], [No title captured]

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