A synthesis of thalidomide

被引：12

作者：

Chang, MY

Chang, CH

Chen, ST ^{[1
]}

Chang, NC

机构：

[1] Acad Sinica, Inst Biol Chem, Taipei 115, Taiwan

[2] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2002年 / 49卷 / 03期

关键词：

glutarimides; thalidomide; formal [3+3] cycloaddition reaction; phthaloylation;

D O I：

10.1002/jccs.200200060

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A synthesis of racemic thalidomide (1) was described and the important formal [3 +3] cycloaddition strategy was a key step. The total yield of thalidomide (1) was 18% in five steps from known 3.

引用

页码：383 / 385

页数：3

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