Transmission of glioblastoma multiforme following bilateral lung transplantation from an affected donor: Case study and review of the literature

被引：58

作者：

Armanios, MY

Grossman, SA

Yang, SC

White, B

Perry, A

Burger, PC

Orens, JB

机构：

[1] Johns Hopkins Med Inst, Dept Oncol, Baltimore, MD 21231 USA

[2] Johns Hopkins Med Inst, Dept Surg, Div Thorac Surg, Baltimore, MD 21231 USA

[3] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21231 USA

[4] Johns Hopkins Med Inst, Dept Med, Div Pulm & Crit Care, Baltimore, MD 21231 USA

[5] Univ Maryland, Sch Med, Baltimore, MD 21201 USA

[6] Washington Univ, Sch Med, St Louis, MO 63110 USA

来源：

NEURO-ONCOLOGY | 2004年 / 6卷 / 03期

关键词：

D O I：

10.1215/S1152851703000474

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Donor-acquired solid organ malignancy is a rare complication of organ transplantation. We report a case of a patient who received bilateral lung transplants for pulmonary fibrosis from a donor with known glioblastoma multiforme (GBM). The lungs, heart, liver, and kidneys were harvested after a lethal intracranial bleed and accepted for transplantation by four centers. An enlarged hilar lymph node sampled at the time of transplant was found to contain GBM. Four months later, the patient developed diffuse interstitial pulmonary infiltrates with mediastinal lymphadenopathy. Lung biopsy confirmed metastatic GBM. The patient died 2 weeks after the diagnosis was established. The patient receiving the donor liver also developed GBM. We present a case study, review of the literature, and suggested interventions to minimize the risk of transmission.

引用

页码：259 / 263

页数：5