Structural aspects of luteinizing hormone receptor - Information from molecular modeling and mutagenesis

被引：14

作者：

Fanelli, F

Puett, D

机构：

[1] Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA

[2] Univ Modena, DTI, I-41100 Modena, Italy

[3] Univ Modena, Dept Chem, I-41100 Modena, Italy

来源：

ENDOCRINE | 2002年 / 18卷 / 03期

关键词：

lutropin receptor; G protein-coupled receptor; molecular modeling; mutagenesis; luteinizing hormone receptor;

D O I：

10.1385/ENDO:18:3:285

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The luteinizing hormone receptor (LHR) is a member of the superfamily of G protein-coupled receptors and, in humans, binds two closely related ligands, members of the heterodimeric glycoprotein hormone family. This receptor is an essential component of the reproductive axis in males and females, and a number of naturally occurring pathophysiologic activating and inactivating mutations have been described. This review deals with the current state of knowledge of the structure of LHR based on molecular modeling and the supporting experimental data from engineered and naturally occurring mutations.

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收藏

页码：285 / 293

页数：9

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