Expression of proinflammatory cytokines tumor necrosis factor-α and interleukin-1β in the brain during experimental Group B streptococcal meningitis

被引：11

作者：

Kim, YS

Honkaniemi, J

Sharp, FR

Täuber, MG

机构：

[1] Tampere Univ, Dept Neurol, Tampere 33521, Finland

[2] Tampere Univ, Dept Rehabil, Tampere 33521, Finland

[3] Tampere Univ Hosp, Tampere 33521, Finland

[4] Drexel Univ, Coll Med, Div Infect Dis, Philadelphia, PA USA

[5] Univ Cincinnati, Dept Neurol, Cincinnati, OH 45267 USA

[6] Univ Cincinnati, Neurosci Program, Cincinnati, OH 45267 USA

[7] Univ Bern, Inst Infect Dis, CH-3010 Bern, Switzerland

来源：

MOLECULAR BRAIN RESEARCH | 2004年 / 128卷 / 01期

关键词：

IL-1; beta; TNF-alpha; meningitis; ependyma; group B streptococcus;

D O I：

10.1016/j.molbrainres.2004.06.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We performed mRNA in situ hybridization for TNF-alpha. and IL-1beta from infant rats with group B streptococcal meningitis. Induction of both cytokines was seen in the ependyma and the meninges at 4 h. Both cytokines were expressed in the brain parenchyma at 12 h. Induction of IL-1beta mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：95 / 102

页数：8

共 35 条

[1]

BAKER CJ, 1990, INFECT DIS, P742

[2] Central nervous system TNFα-mRNA expression during rabbit experimental pneumococcal meningitis [J].