Vitamin E and neurodegenerative disorders associated with oxidative stress

被引：124

作者：

Butterfield, DA ^{[1
]}

Castegna, A

Drake, J

Scapagnini, G

Calabrese, V

机构：

[1] Univ Kentucky, Dept Chem, Ctr Membrane Sci, Lexington, KY 40506 USA

[2] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40506 USA

[3] Blanchette Rockefeller Neurosci Inst, Rockville, MD 20850 USA

[4] Univ Catania, Dipartimento Sci Chim, Sec Biochim & Biol Mol, I-95125 Catania, Italy

来源：

NUTRITIONAL NEUROSCIENCE | 2002年 / 5卷 / 04期

关键词：

vitamin E; oxidative stress; neurodegenerative disorders; protein oxidation; lipid peroxidation;

D O I：

10.1080/10284150290028954

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several neurodegenerative disorders are associated with oxidative stress that is manifested by lipid peroxidation, protein oxidation and other markers. Included in these disorders in which oxidative stress is thought to play an important role in their pathogenesis are Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), tardive dyskinesia, Huntington's disease (HD), and multiple sclerosis. This review presents some of the chemistry of vitamin E as an antioxidant and summarizes studies in which vitamin E has been employed in these disorders and models thereof.

引用

页码：229 / 239

页数：11

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