Expression of interleukin-6 in human dorsal root ganglion cells

被引：13

作者：

Nordlind, K ^{[1
]}

Eriksson, L

Seiger, Å

Bakhiet, M

机构：

[1] Univ Uppsala Hosp, Dept Med Sci, S-75185 Uppsala, Sweden

[2] Univ Uppsala Hosp, Dept Genet & Pathol, S-75185 Uppsala, Sweden

[3] Huddinge Hosp, Karolinska Inst, Dept Clin Neurosci Occupat Therapy & Elderly Care, S-14186 Huddinge, Sweden

[4] Huddinge Hosp, Karolinska Inst, Dept Infect Dis, S-14186 Huddinge, Sweden

来源：

NEUROSCIENCE LETTERS | 2000年 / 280卷 / 02期

关键词：

dorsal root ganglia; IL-6; immunohistochemistry; in situ hybridization; mRNA;

D O I：

10.1016/S0304-3940(00)00772-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The expression of Interleukin-6 (IL-6) was studied in normal dorsal root ganglia (DRG) of juvenile and foetal humans, using immunohistochemistry and in situ hybridization techniques. There was an expression of IL-6-like immunoreactivity in more than 75% out of neuronal cells in the juvenile ganglia with a peripheral localization, and also an expression in the foetal ganglion cells. There was a co-localization of IL-6 with substance P (SP) and calcitonin gene-related peptide (CGRP) in more than 60% of the DRG cells, respectively. By in situ hybridization 0.9% of the cells in the juvenile ganglia and 1.1% of the cells in the foetal ganglia showed a positive signal for IL-6. In addition, expression of IL-6 was found in juvenile medulla spinalis, preferentially in the white matter. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：139 / 142

页数：4

共 21 条

[1]

BRAKENHOFF JPJ, 1994, J BIOL CHEM, V269, P86

[2] SENSITIVE MESSENGER-RNA DETECTION USING UNFIXED TISSUE - COMBINED RADIOACTIVE AND NONRADIOACTIVE INSITU HYBRIDIZATION HISTOCHEMISTRY [J].

DAGERLIND, A ;

FRIBERG, K ;

BEAN, AJ ;

HOKFELT, T .

HISTOCHEMISTRY, 1992, 98 (01) :39-49

[3] NEUROPOIETIC CYTOKINES AND ACTIVIN-A DIFFERENTIALLY REGULATE THE PHENOTYPE OF CULTURED SYMPATHETIC NEURONS [J].

FANN, MJ ;

PATTERSON, PH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (01) :43-47

[4] IDENTIFICATION OF INTERLEUKIN-6 (IL-6) EXPRESSING NEURONS IN THE CEREBELLUM AND HIPPOCAMPUS OF NORMAL ADULT-RATS [J].

GADIENT, RA ;

OTTEN, U .

NEUROSCIENCE LETTERS, 1994, 182 (02) :243-246

[5] Interleukin-6 (IL-6) - A molecule with both beneficial and destructive potentials [J].

Gadient, RA ;

Otten, UH .

PROGRESS IN NEUROBIOLOGY, 1997, 52 (05) :379-390

[6] Postnatal expression of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) mRNAs in rat sympathetic and sensory ganglia [J].

Gadient, RA ;

Otten, U .

BRAIN RESEARCH, 1996, 724 (01) :41-46

[7] INTERLEUKIN-6 PRODUCTION IN THE CENTRAL-NERVOUS-SYSTEM DURING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS [J].

GIJBELS, K ;

VANDAMME, J ;

PROOST, P ;

PUT, W ;

CARTON, H ;

BILLIAU, A .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (01) :233-235

[8] Physiological and pathological roles of interleukin-6 in the central nervous system [J].

Gruol, DL ;

Nelson, TE .

MOLECULAR NEUROBIOLOGY, 1997, 15 (03) :307-339

[9] ELEVATED LEVELS OF INTERLEUKIN-6 IN CEREBROSPINAL-FLUID FROM PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS AND CENTRAL-NERVOUS-SYSTEM INVOLVEMENT [J].

HIROHATA, S ;

MIYAMOTO, T .

ARTHRITIS AND RHEUMATISM, 1990, 33 (05) :644-649

[10] INTERLEUKIN-6 AND TRANSFORMING GROWTH-FACTOR-BETA-1 MESSENGER-RNAS ARE INDUCED IN RAT FACIAL NUCLEUS FOLLOWING MOTONEURON AXOTOMY [J].

KIEFER, R ;

LINDHOLM, D ;

KREUTZBERG, GW .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1993, 5 (07) :775-781

← 1 2 3 →