INTERLEUKIN-6 PRODUCTION IN THE CENTRAL-NERVOUS-SYSTEM DURING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

被引：145

作者：

GIJBELS, K ^{[1
]}

VANDAMME, J ^{[1
]}

PROOST, P ^{[1
]}

PUT, W ^{[1
]}

CARTON, H ^{[1
]}

BILLIAU, A ^{[1
]}

机构：

[1] CATHOLIC UNIV LEUVEN,SCH MED,B-3000 LOUVAIN,BELGIUM

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1990年 / 20卷 / 01期

关键词：

D O I：

10.1002/eji.1830200134

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin 6 (IL6) is one of the major inflammation‐associated cytokines. Elevated serum or tissue levels of IL 6 have been reported to occur in several human diseases, including infections of the central nervous system (CNS), but not in non‐infectious CNS inflammation, e.g. multiple sclerosis. While studying experimental autoimmune encephalomyelitis (EAE) as an animal model for autoimmune inflammation of the CNS, we found increased IL 6 levels in the CNS of mice suffering from a lethal form of the disease. IL 6 levels in the spleens and sera were not significantly increased. These findings are indicative of local production of IL6 in the CNS during EAE, and represent the first demonstration of IL6 production in non‐infectious CNS inflammatory disease. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：233 / 235

页数：3

共 16 条

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