CD1d-restricted T-cell subsets and dendritic cell function in autoimmunity

被引：16

作者：

Bollyky, PL ^{[1
]}

Wilson, SB ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Diabet Res Labs, Cambridge, MA 02139 USA

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2004年 / 82卷 / 03期

关键词：

autoimmunity; dendritic cell; diabetes; immunoregulation; iNKT cell;

D O I：

10.1111/j.0818-9641.2004.01253.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

CD1-restricted T cells have been shown to play a critical role in host defence, tumour surveillance, and maintenance of tolerance. However, immunologic outcomes resulting from activation of CD1d-restricted T cells can be either beneficial or deleterious. A major mechanism by which CD1d-restricted T cells are thought to exert immunoregulatory control is via effects on dendritic cell (DC) differentiation and migration. Important functional subsets of CD1d-restricted T cells are also known to exist and the potential implications for preferential subset activations are discussed.

引用

页码：307 / 314

页数：8

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