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Mantle cell lymphoma: New treatments targeted to the biology

被引：6
作者：
Bertoni, F
Ghielmini, M
Cavalli, F
Cotter, FE
Zucca, E [1 ]
机构：
[1] Osped San Giovanni Bellinzona, Div Med Oncol, Oncol Inst So Switzerland, CH-6500 Bellinzona, Switzerland
[2] Barts & London Queen Marys Sch Med & Dent, Dept Expt Hematol, London, England
来源：
CLINICAL LYMPHOMA | 2002年 / 3卷 / 02期
关键词：
monoclonal antibodies; rituximab; tositumomab; ibritumomab; apoptosis; CD20; proteasome inhibitors;
D O I：
10.3816/CLM.2002.n.014
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mantle cell lymphoma (MCL) represents a distinct lymphoma subtype. The prognosis of patients with MCL is the poorest among lymphoma patients and the response to conventional treatments is inadequate. New approaches targeted to the biology of MCL and the genetics underlying the disease are being studied. Monoclonal antibodies directed at molecules expressed on MCL cells are already used in the clinical setting. This article reviews the literature on these and other new possible treatment modalities.
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页码：90 / 96
页数：7
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