The worm turns for antimicrobial discovery

被引：9

作者：

Bhavsar, Amit P. ^{[1
]}

Brown, Eric D. ^{[1
]}

机构：

[1] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON, Canada

来源：

NATURE BIOTECHNOLOGY | 2006年 / 24卷 / 09期

关键词：

D O I：

10.1038/nbt0906-1098

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

High-throughput screening using an in vivo infection model identifies nontraditional antimicrobials.

引用

页码：1098 / 1100

页数：4

共 9 条

[1] New targets and screening approaches in antimicrobial drug discovery [J].

Brown, ED ;

Wright, GD .

CHEMICAL REVIEWS, 2005, 105 (02) :759-774

[2] Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli [J].

Gauthier, A ;

Robertson, ML ;

Lowden, M ;

Ibarra, JA ;

Puente, JL ;

Finlay, BB .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (10) :4101-4109

[3] Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization [J].

Hung, DT ;

Shakhnovich, EA ;

Pierson, E ;

Mekalanos, JJ .

SCIENCE, 2005, 310 (5748) :670-674

[4] Targeting bacterial virulence:: Inhibitors of type III secretion in Yersinia [J].

Kauppi, AM ;

Nordfelth, R ;

Uvell, H ;

Wolf-Watz, H ;

Elofsson, M .

CHEMISTRY & BIOLOGY, 2003, 10 (03) :241-249

[5] A small-molecule screen in C-elegans yields a new calcium channel antagonist [J].

Kwok, TCY ;

Ricker, N ;

Fraser, R ;

Chan, AW ;

Burns, A ;

Stanley, EF ;

McCourt, P ;

Cutler, SR ;

Roy, PJ .

NATURE, 2006, 441 (7089) :91-95

[6] Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility [J].

Li, XM ;

Zolli-Juran, M ;

Cechetto, JD ;

Daigle, DM ;

Wright, GD ;

Brown, ED .

CHEMISTRY & BIOLOGY, 2004, 11 (10) :1423-1430

[7] Identification of novel antimicrobials using a live-animal infection model [J].

Moy, Terence I. ;

Ball, Anthony R. ;

Anklesaria, Zafia ;

Casadei, Gabriele ;

Lewis, Kim ;

Ausubel, Frederick M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (27) :10414-10419

[8] Small-molecule inhibitors specifically targeting type III secretion [J].

Nordfelth, R ;

Kauppi, AM ;

Norberg, HA ;

Wolf-Watz, H ;

Elofsson, M .

INFECTION AND IMMUNITY, 2005, 73 (05) :3104-3114

[9] Platensimycin is a selective FabF inhibitor with potent antibiotic properties [J].

Wang, J ;

Soisson, SM ;

Young, K ;

Shoop, W ;

Kodali, S ;

Galgoci, A ;

Painter, R ;

Parthasarathy, G ;

Tang, YS ;

Cummings, R ;

Ha, S ;

Dorso, K ;

Motyl, M ;

Jayasuriya, H ;

Ondeyka, J ;

Herath, K ;

Zhang, CW ;

Hernandez, L ;

Allocco, J ;

Basilio, A ;

Tormo, JR ;

Genilloud, O ;

Vicente, F ;

Pelaez, F ;

Colwell, L ;

Lee, SH ;

Michael, B ;

Felcetto, T ;

Gill, C ;

Silver, LL ;

Hermes, JD ;

Bartizal, K ;

Barrett, J ;

Schmatz, D ;

Becker, JW ;

Cully, D ;

Singh, SB .

NATURE, 2006, 441 (7091) :358-361

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