Regulatory T cells in transplantation

被引：51

作者：

Karim, M ^{[1
]}

Bushell, AR ^{[1
]}

Wood, KJ ^{[1
]}

机构：

[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg, Oxford OX3 9DU, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(02)00379-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There has recently been an explosion of renewed interest in regulatory T cells, particularly those within the CD4(+)CD25(+) population. It is becoming increasingly apparent that these cells exist not only as naturally occurring cells that may contribute to the maintenance of self-tolerance, but they also have the potential to prevent rejection of allografts in experimental models. Such cells have now been identified in humans as well as in rodents. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：584 / 591

页数：8

共 80 条

[1] Regulatory CD4 T cells control the size of the peripheral activated/memory CD4 T cell compartment [J].

Annacker, O ;

Burlen-Defranoux, O ;

Pimenta-Araujo, R ;

Cumano, A ;

Bandeira, A .

JOURNAL OF IMMUNOLOGY, 2000, 164 (07) :3573-3580

[2] Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation [J].

Asano, M ;

Toda, M ;

Sakaguchi, N ;

Sakaguchi, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :387-396

[3] An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation [J].

Asseman, C ;

Mauze, S ;

Leach, MW ;

Coffman, RL ;

Powrie, F .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (07) :995-1003

[4] CD4+CD25high regulatory cells in human peripheral blood [J].

Baecher-Allan, C ;

Brown, JA ;

Freeman, GJ ;

Hafler, DA .

JOURNAL OF IMMUNOLOGY, 2001, 167 (03) :1245-1253

[5] In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines [J].

Barrat, FJ ;

Cua, DJ ;

Boonstra, A ;

Richards, DF ;

Crain, C ;

Savelkoul, HF ;

de Waal-Malefyt, R ;

Coffman, RL ;

Hawrylowicz, CM ;

O'Garra, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) :603-616

[6] Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4+25+ immunoregulatory T cells [J].

Bensinger, SJ ;

Bandeira, A ;

Jordan, MS ;

Caton, AJ ;

Laufer, TM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (04) :427-438

[7] Murine renal allografts: Spontaneous acceptance is associated with regulated T cell-mediated immunity [J].

Bickerstaff, AA ;

Wang, JJ ;

Pelletier, RP ;

Orosz, CG .

JOURNAL OF IMMUNOLOGY, 2001, 167 (09) :4821-4827

[8] B cells and professional APCs recruit regulatory T cells via CCL4 [J].

Bystry, RS ;

Aluvihare, V ;

Welch, KA ;

Kallikourdis, M ;

Betz, AG .

NATURE IMMUNOLOGY, 2001, 2 (12) :1126-1132

[9] Tolerization of dendritic cells by TS cells:: the crucial role of inhibitory receptors ILT3 and ILT4 [J].

Chang, CC ;

Ciubotariu, R ;

Manavalan, JS ;

Yuan, J ;

Colovai, AI ;

Piazza, F ;

Lederman, S ;

Colonna, M ;

Cortesini, R ;

Dalla-Favera, R ;

Suciu-Foca, N .

NATURE IMMUNOLOGY, 2002, 3 (03) :237-243

[10] Oral tolerance in myelin basic protein T-cell receptor transgenic mice: Suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells [J].

Chen, YH ;

Inobe, J ;

Kuchroo, VK ;

Baron, JL ;

Janeway, CA ;

Weiner, HL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (01) :388-391

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