The ribosome at higher resolution - The donut takes shape

被引：21

作者：

Frank, J ^{[1
]}

机构：

[1] SUNY ALBANY, DEPT BIOMED SCI, ALBANY, NY 12201 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 02期

关键词：

D O I：

10.1016/S0959-440X(97)80035-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Major new results in the 3D cryoimaging of ribosomes have advanced our understanding of ribosomal structure and function. For the first time, 3D difference maps have been used to image tRNA molecules in situ. With this new technology, the stage is set for detailed ligand-binding experiments that explore the binding states of elongation factors and tRNA, and that pinpoint locations of proteins and RNA on the surface of the ribosome.

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页码：266 / 272

页数：7

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