Diagnosis and treatment of pediatric nonalcoholic steatohepatitis and the implications for bariatric surgery

被引：47

作者：

Pardee, Perrie E.

Lavine, Joe E.

Schwimmer, Jeffrey B. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Pediat, Div Gastroenterol Hepatol & Nutr, San Diego, CA 92103 USA

来源：

SEMINARS IN PEDIATRIC SURGERY | 2009年 / 18卷 / 03期

关键词：

Cirrhosis; Histology; Obesity; Nonalcoholic fatty liver disease; Children; FATTY-LIVER-DISEASE; VITAMIN-E TREATMENT; OBESE CHILDREN; INSULIN-RESISTANCE; METABOLIC SYNDROME; PREVALENCE; FIBROSIS; TRIAL; RISK; HISTOPATHOLOGY;

D O I：

10.1053/j.sempedsurg.2009.04.004

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

This review focuses on the diagnosis, risk factors, prevalence, pathogenesis and treatment of pediatric nonalcoholic steatohepatitis (NASH). NASH is a progressive form of nonalcoholic fatty liver disease (NAFLD), the most common cause of chronic liver disease in children. The factors that account for differences between children with NASH and children with milder forms of NAFLD are unclear. The diagnosis of NASH requires interpretation of liver histology because no noninvasive markers predict the presence or severity of NASH. There is no proven treatment for NASH. Several clinical trials for NAFLD are in progress, however, clinical trials focusing on NASH are needed. Heightened physician awareness of NAFLD, NASH, and associated risk factors is important to identify and treat affected children. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：144 / 151

页数：8

共 55 条

[51]

Vitamin E treatment in pediatric obesity-related liver disease: A randomized study [J].