Transcriptional Control of Endothelial Cell Development

被引：307

作者：

De Val, Sarah ^{[1
,2
]}

Black, Brian L. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94158 USA

来源：

DEVELOPMENTAL CELL | 2009年 / 16卷 / 02期

关键词：

EMBRYONIC VASCULAR DEVELOPMENT; LINEAGE-SPECIFIC EXPRESSION; TIE GENE PROMOTER; GROWTH-FACTOR; LYMPHATIC VASCULATURE; ETS FAMILY; CARDIOVASCULAR DEVELOPMENT; REGULATES ANGIOGENESIS; TRANSGENIC MICE; VE-CADHERIN;

D O I：

10.1016/j.devcel.2009.01.014

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The transcription factors that regulate endothelial cell development have been a focus of active research for several years, and many players in the endothelial transcriptional program have been identified. This review discusses the function of several major regulators of endothelial transcription, including members of the Sox, Ets, Forkhead, GATA, and Kruppel-like families. This review also highlights recent developments aimed at unraveling the combinatorial mechanisms and transcription factor interactions that regulate endothelial cell specification and differentiation during vasculogenesis and angiogenesis.

引用

页码：180 / 195

页数：16

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