Consequences of human cytomegalovirus mimicry

被引：33

作者：

Michelson, S ^{[1
]}

机构：

[1] Inst Pasteur, Unite Immunol Virale, F-75724 Paris 15, France

来源：

HUMAN IMMUNOLOGY | 2004年 / 65卷 / 05期

关键词：

HCMV; mimicry; chemokine receptors; apoptosis;

D O I：

10.1016/j.humimm.2004.02.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The HCMV genome has evolved with its host by incorporating a series of genes that are homologous to, or functionally mimic, cellular genes. Some are designed to counteract the stress of infection on the host cell, notably the viral antiapoptotic proteins (vICA, vMIA). Others potentially help the infected cell maintain a low immunologic profile. These include virus-encoded chemokine receptors (UL33, UL78, US27, US28), FcRs (gp TRL11/IRL11, gp UL119-118), and proteins that directly or indirectly thwart natural killer cell activity (UL16, gpUL40). In addition, some viral proteins may play a role in immunopathology because of fortuitous cross-reactivity with host cell proteins. This overview discusses how these proteins affect the life of the host cell and its immediate neighbors. Human Immunology 651, 465-475 (2004). (C) American Society for Histocompatibility and Immunogenetics, 2004. Published by Elsevier Inc.

引用

页码：465 / 475

页数：11

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