Consequences of human cytomegalovirus mimicry

被引：33

作者：

Michelson, S ^{[1
]}

机构：

[1] Inst Pasteur, Unite Immunol Virale, F-75724 Paris 15, France

来源：

HUMAN IMMUNOLOGY | 2004年 / 65卷 / 05期

关键词：

HCMV; mimicry; chemokine receptors; apoptosis;

D O I：

10.1016/j.humimm.2004.02.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The HCMV genome has evolved with its host by incorporating a series of genes that are homologous to, or functionally mimic, cellular genes. Some are designed to counteract the stress of infection on the host cell, notably the viral antiapoptotic proteins (vICA, vMIA). Others potentially help the infected cell maintain a low immunologic profile. These include virus-encoded chemokine receptors (UL33, UL78, US27, US28), FcRs (gp TRL11/IRL11, gp UL119-118), and proteins that directly or indirectly thwart natural killer cell activity (UL16, gpUL40). In addition, some viral proteins may play a role in immunopathology because of fortuitous cross-reactivity with host cell proteins. This overview discusses how these proteins affect the life of the host cell and its immediate neighbors. Human Immunology 651, 465-475 (2004). (C) American Society for Histocompatibility and Immunogenetics, 2004. Published by Elsevier Inc.

引用

页码：465 / 475

页数：11

共 116 条

[91] ACTIVATION OF THE MAJOR IMMEDIATE EARLY GENE OF HUMAN CYTOMEGALO-VIRUS BY CIS-ACTING ELEMENTS IN THE PROMOTER-REGULATORY SEQUENCE AND BY VIRUS-SPECIFIC TRANS-ACTING COMPONENTS [J].

STINSKI, MF ;

ROEHR, TJ .

JOURNAL OF VIROLOGY, 1985, 55 (02) :431-441

[92] The human cytomegalovirus chemokine receptor US28 mediates vascular smooth muscle cell migration [J].

Streblow, DN ;

Soderberg-Naucler, C ;

Vieira, J ;

Smith, P ;

Wakabayashi, E ;

Ruchti, F ;

Mattison, K ;

Altschuler, Y ;

Nelson, JA .

CELL, 1999, 99 (05) :511-520

[93] UL16-Binding proteins, novel MHC class I-Related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells [J].

Sutherland, CL ;

Chalupny, NJ ;

Schooley, K ;

VandenBos, T ;

Cosman, D .

JOURNAL OF IMMUNOLOGY, 2002, 168 (02) :671-679

[94] Effects of human cytomegalovirus immediate-early proteins on p53-mediated apoptosis in coronary artery smooth muscle cells [J].

Tanaka, K ;

Zou, JP ;

Takeda, K ;

Ferrans, VJ ;

Sandford, GR ;

Johnson, TM ;

Finkel, T ;

Epstein, SE .

CIRCULATION, 1999, 99 (13) :1656-1659

[95]

TAUB DD, 1995, J IMMUNOL, V155, P3877

[96] beta Chemokines costimulate lymphocyte cytolysis, proliferation, and lymphokine production [J].

Taub, DD ;

Ortaldo, JR ;

TurcovskiCorrales, SM ;

Key, ML ;

Longo, DL ;

Murphy, WJ .

JOURNAL OF LEUKOCYTE BIOLOGY, 1996, 59 (01) :81-89

[97] Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40 [J].

Tomasec, P ;

Braud, VM ;

Rickards, C ;

Powell, MB ;

McSharry, BP ;

Gadola, S ;

Cerundolo, V ;

Borysiewicz, LK ;

McMichael, AJ ;

Wilkinson, GWG .

SCIENCE, 2000, 287 (5455) :1031-1033

[98] Cytomegalovirus infection induces antiendothelial cell antibodies in cardiac and renal allograft recipients [J].

Toyoda, M ;

Galfayan, K ;

Galera, OA ;

Petrosian, A ;

Czer, LSC ;

Jordan, SC .

TRANSPLANT IMMUNOLOGY, 1997, 5 (02) :104-111

[99] Immunologic characterization of anti-endothelial cell antibodies induced by cytomegalovirus infection [J].

Toyoda, M ;

Petrosian, A ;

Jordan, SC .

TRANSPLANTATION, 1999, 68 (09) :1311-1318

[100]

Tsai HL, 1996, J BIOL CHEM, V271, P3534

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