Synthesis and preliminary evaluation of (S)-(2-[F-18]fluoro-4,5-dihydroxyphenyl)-2-methyl L-alanine, (S)-[F-18]-FMEDOPA, a potentially improved imaging agent for the presynaptic dopaminergic nervous system

被引：4

作者：

Yost, Y ^{[1
]}

Conway, T ^{[1
]}

机构：

[1] VET ADM MED CTR,PET IMAGING SERV,MINNEAPOLIS,MN 55417

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1996年 / 23卷 / 07期

关键词：

PET imaging agent; dopaminergic nervous system; (2[F-18]fluoro-4,5-dihydroxyphenyl)-2-methyl L-alanine; F-18]-FMEDOPA; F-18]-FDOPA;

D O I：

10.1016/S0969-8051(96)00056-X

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The synthesis and preliminary rat biodistribution studies of (S)-(2-[F-18]fluoro-4,5-dihydroxyphenyl)-2-methyl L-alanine, (S)-[F-18]-FMEDOPA, a potentially improved imaging agent for the presynaptic dopaminergic nervous system, are reported. (S)-[F-18]-FMEDOPA produces a higher striatum-to-cerebellum (S/C) radioactivity ratio than the currently used PET imaging agent, (S)-[F-18]-FDOPA, does at 180 min after administration. Copyright (C) 1996 Elsevier Science Inc.

引用

页码：857 / 865

页数：9

共 54 条

[31] FLUORINATION OF (E)-BETA-(FLUOROMETHYLENE)-M-TYROSINE - REGIOSELECTIVE SYNTHESIS OF 4-FLUORO-(E)-BETA-(FLUOROMETHYLENE)-M-TYROSINE [J].