Advances in drug delivery systems (DDSs) to release growth factors for wound healing and skin regeneration

被引：241

作者：

Gainza, Garazi ^{[1
,2
]}

Villullas, Silvia ^{[3
]}

Pedraz, Jose Luis ^{[1
,2
]}

Hernandez, Rosa Maria ^{[1
,2
]}

Igartua, Manoli ^{[1
,2
]}

机构：

[1] Univ Basque Country, Lab Pharmaceut, Sch Pharm, NanoBioCel Grp, Vitoria, Spain

[2] Biomed Res Networking Ctr Bioengn Biomat & Nanome, Vitoria, Spain

[3] Biopraxis Res AIE, Minano 01510, Spain

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2015年 / 11卷 / 06期

关键词：

Growth factor; Drug delivery system; Microparticle; Nanosphere; Skin regeneration; Wound healing; SOLID LIPID NANOPARTICLES; EXTREMITY DIABETIC ULCERS; FACTOR-BB BECAPLERMIN; HYALURONIC-ACID; DOUBLE-BLIND; PRESSURE ULCERS; ANIMAL-MODELS; CLINICAL-EVALUATION; PROTEIN DELIVERY; CUTANEOUS WOUNDS;

D O I：

10.1016/j.nano.2015.03.002

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

Current advances in novel drug delivery systems (DDSs) to release growth factors (GFs) represent a great opportunity to develop new therapies or enhance the effectiveness of available medical treatments. These advances are particularly relevant to the field of regenerative medicine, challenging healthcare issues such as wound healing and skin repair. To this end, biocompatible biomaterials have been extensively studied to improve in vivo integration of DDSs, to enhance the bioactivity of the released drugs and to deliver bioactive molecules in a localised and controlled manner. Thus, this review presents an overview of DDSs to release GFs for skin regeneration, particularly emphasising on (i) polymeric micro and nanospheres, (ii) lipid nanoparticles, (iii) nanofibrous structures, (iv) hydrogels and (v) scaffolds. In addition, this review summarises the current animal models available for studying wound healing and the clinical trials and marketed medications based on GF administration indicated for chronic wound treatment. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：1551 / 1573

页数：23

共 160 条

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