D-α-tocopheryl polyethylene glycol 1000 succinate functionalized nanographene oxide for cancer therapy

被引：37

作者：

de Melo-Diogo, Duarte ^{[1
]}

Pais-Silva, Cleide ^{[1
]}

Costa, Elisabete C. ^{[1
]}

Louro, Ricardo O. ^{[2
]}

Correia, Ilidio J. ^{[1
]}

机构：

[1] Univ Beira Interior, CICS, P-6200506 Covilha, Portugal

[2] Univ Nova Lisboa, ITQB Inst Tecnol Quim & Biol Antonio Xavier, P-2780157 Oeiras, Portugal

来源：

NANOMEDICINE | 2017年 / 12卷 / 05期

关键词：

breast cancer; nanographene oxide; PEGylated Vitamin E; phototherapy; TPGS; VITAMIN-E TPGS; REDUCED GRAPHENE OXIDE; CHEMO-PHOTOTHERMAL THERAPY; ANTICANCER DRUG-DELIVERY; TARGETED CO-DELIVERY; IN-VIVO; CARBON NANOTUBES; BREAST-CANCER; BIOMEDICAL APPLICATIONS; MULTIDRUG-RESISTANCE;

D O I：

10.2217/nnm-2016-0384

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Aim: To evaluate the therapeutic capacity of D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS)-functionalized nanographene oxide (nGO) in breast cancer cells. Methods: TPGS-functionalized nGO-based materials were obtained through two different approaches: a simple sonication method and a one-pot hydrothermal treatment. Results: TPGS coating successfully improved the stability of the nGO-based materials. The nanomaterials that underwent the hydrothermal procedure generated a 1.4- to 1.6- fold higher temperature variation under near infrared laser irradiation than those prepared only by sonication. In vitro, the TPGS/nGO derivatives reduced breast cancer cells' viability and had an insignificant effect on healthy cells. Furthermore, the combined application of TPGS/nGO derivatives and near infrared light generated an improved therapeutic effect. Conclusion: TPGS/nGO derivatives are promising materials for breast cancer phototherapy.

引用

页码：443 / 456

页数：14

共 69 条

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