Stability of mefenamic acid in the inclusion complex with β-cyclodextrin in the solid phase

被引：16

作者：

Hladon, T ^{[1
]}

Pawlaczyk, J ^{[1
]}

Szfran, B ^{[1
]}

机构：

[1] Karol Marcinkowski Univ Med Sci, Dept Inorgan & Analyt Chem, PL-60780 Poznan, Poland

来源：

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 1999年 / 35卷 / 03期

关键词：

beta-cyclodextrin complex; mefenamic acid; X-ray and thermogravimetric analyses; complex stability constants; stability studies;

D O I：

10.1023/A:1008048612736

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The inclusion complex of mefenamic acid with beta-cyclodextrin was obtained by the method of coprecipitation from diethyl ether. The product was identified by the thermogravimetric and X-ray methods. The complex stability constants were determined by the potentiometric method. The effect of beta-CD on the solubility and stability of mefenamic acid was analysed.

引用

页码：497 / 506

页数：10