Mapping the Epigenetic Basis of Complex Traits

被引：338

作者：

Cortijo, Sandra ^{[1
]}

Wardenaar, Rene ^{[2
]}

Colome-Tatche, Maria ^{[2
]}

Gilly, Arthur ^{[3
]}

Etcheverry, Mathilde ^{[1
]}

Labadie, Karine ^{[3
]}

Caillieux, Erwann ^{[1
]}

Hospital, Frederic ^{[4
]}

Aury, Jean-Marc ^{[3
]}

Wincker, Patrick ^{[3
,5
,6
]}

Roudier, Francois ^{[1
]}

Jansen, Ritsert C. ^{[2
]}

Colot, Vincent ^{[1
]}

Johannes, Frank ^{[2
]}

机构：

[1] Ecole Normale Super, CNRS, UMR 8197, Inst Biol,INSERM,U1024, F-75005 Paris, France

[2] Univ Groningen, GBB, Groningen Bioinformat Ctr, NL-9747 AG Groningen, Netherlands

[3] CEA, IG, Genoscope, F-91057 Evry, France

[4] INRA, UMR Genet Anim & Biol Integrat 1313, F-78352 Jouy En Josas, France

[5] CNRS, UMR 8030, CP5706, Evry, France

[6] Univ Evry, CP5706, Evry, France

来源：

SCIENCE | 2014年 / 343卷 / 6175期

关键词：

DNA METHYLATION; ARABIDOPSIS-THALIANA; PATTERNS; ANIMALS; PLANTS;

D O I：

10.1126/science.1248127

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Quantifying the impact of heritable epigenetic variation on complex traits is an emerging challenge in population genetics. Here, we analyze a population of isogenic Arabidopsis lines that segregate experimentally induced DNA methylation changes at hundreds of regions across the genome. We demonstrate that several of these differentially methylated regions (DMRs) act as bona fide epigenetic quantitative trait loci (QTL(epi)), accounting for 60 to 90% of the heritability for two complex traits, flowering time and primary root length. These QTL(epi) are reproducible and can be subjected to artificial selection. Many of the experimentally induced DMRs are also variable in natural populations of this species and may thus provide an epigenetic basis for Darwinian evolution independently of DNA sequence changes.

引用

页码：1145 / 1148

页数：4

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