共 45 条
Naive T-cell depletion related to infection by X4 human immunodeficiency virus type 1 in poor immunological responders to highly active antiretroviral therapy
被引:55
作者:

Delobel, Pierre
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机构: CHU Purpan, Virol Lab, EA2046, IFR30, F-31059 Toulouse 9, France

Nugeyre, Marie-Therese
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机构: CHU Purpan, Virol Lab, EA2046, IFR30, F-31059 Toulouse 9, France

Cazabat, Michelle
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h-index: 0
机构: CHU Purpan, Virol Lab, EA2046, IFR30, F-31059 Toulouse 9, France

Sandres-Saune, Karine
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机构: CHU Purpan, Virol Lab, EA2046, IFR30, F-31059 Toulouse 9, France

Pasquier, Christophe
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h-index: 0
机构: CHU Purpan, Virol Lab, EA2046, IFR30, F-31059 Toulouse 9, France

Cuzin, Lise
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h-index: 0
机构: CHU Purpan, Virol Lab, EA2046, IFR30, F-31059 Toulouse 9, France

Marchou, Bruno
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h-index: 0
机构: CHU Purpan, Virol Lab, EA2046, IFR30, F-31059 Toulouse 9, France

Massip, Patrice
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h-index: 0
机构: CHU Purpan, Virol Lab, EA2046, IFR30, F-31059 Toulouse 9, France

Cheynier, Remi
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h-index: 0
机构: CHU Purpan, Virol Lab, EA2046, IFR30, F-31059 Toulouse 9, France

Barre-Sinoussi, Francoise
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h-index: 0
机构: CHU Purpan, Virol Lab, EA2046, IFR30, F-31059 Toulouse 9, France

Izopet, Jacques
论文数: 0 引用数: 0
h-index: 0
机构: CHU Purpan, Virol Lab, EA2046, IFR30, F-31059 Toulouse 9, France

Israel, Nicole
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h-index: 0
机构: CHU Purpan, Virol Lab, EA2046, IFR30, F-31059 Toulouse 9, France
机构:
[1] CHU Purpan, Virol Lab, EA2046, IFR30, F-31059 Toulouse 9, France
[2] Inst Pasteur, Unite Regulat Infect Retrovirales, Paris, France
[3] CHU Toulouse, Serv Malad Infect & Trop, Toulouse, France
[4] Inst Pasteur, Unite Virus Lents, Paris, France
关键词:
D O I:
10.1128/JVI.00965-06
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
The reasons for poor CD4(+) T-cell recovery in some human immunodeficiency virus (HIV)-infected subjects despite effective highly active antiretroviral therapy (HAART) remain unclear. We recently reported that CXCR4-using (X4) HIV-1 could be gradually selected in cellular reservoirs during sustained HAART. Because of the differential expression of HIV-1 coreceptors CCR5 and CXCR4 on distinct T-cell subsets, the residual replication of R5 and X4 viruses could have different impacts on T-cell homeostasis during immune reconstitution on HAART. We examined this hypothesis and the mechanisms of CD4(+) T-cell restoration by comparing the virological and immunological features of 15 poor and 15 good immunological responders to HAART. We found a high frequency of X4 viruses in the poor immunological responders. But the levels of intrathymic proliferation of the two groups were similar regardless of whether they were infected by R5 or X4 virus. The frequency of recent thymic emigrants in the poor immunological responders was also similar to that found in the good immunological responders, despite their reduced numbers of naive CD4(+) T cells. Our data, rather, suggest that the naive T-cell compartment is drained by a high rate of mature naive cell loss in the periphery due to bystander apoptosis or activation-induced differentiation. X4 viruses could play a role in the depletion of naive T cells in poor immunological responders to HAART by triggering persistent T-cell activation and bystander apoptosis via gpl20-CXCR4 interactions.
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页码:10229 / 10236
页数:8
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