Control of enzyme hydration in penicillin amidase catalysed synthesis of amide bond

被引：19

作者：

Ebert, C ^{[1
]}

Gardossi, L ^{[1
]}

Linda, P ^{[1
]}

机构：

[1] UNIV TRIESTE, DIPARTIMENTO SCI FARMACEUT, I-34127 TRIESTE, ITALY

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 52期

关键词：

D O I：

10.1016/S0040-4039(97)82968-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Penicillin amidase catalyses the synthesis of amide bond in very high yield (>98%), using equimolar concentrations of the amine and the phenylacetic components. In situ hydrated phosphates were employed for controlling the water activity in a benzene/water system (97:3 v/v), where the water is taken up by the salt with formation of the hydrated species. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：9377 / 9380

页数：4

共 28 条

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