Molecular variations in Th1-specific cell surface gene Tim-3

被引：45

作者：

Chae, SC

Song, JH

Pounsambath, P

Yuan, HY

Lee, JH

Kim, JJ

Lee, YC

Chung, HT ^{[1
]}

机构：

[1] Wonkwang Univ, Sch Med, Genome Res Ctr Immune Disorders, Iksan 570749, Chonbuk, South Korea

[2] Wonkwang Univ, Sch Med, Dept Otolaryngol, Iksan 570749, Chonbuk, South Korea

[3] Wonkwang Univ, Sch Med, Dept Anat, Iksan 570749, Chonbuk, South Korea

[4] Chonbuk Natl Univ, Sch Med, Res Ctr Allerg Immune Dis, Dept Internal Med, Chonju 560180, Chonbuk, South Korea

[5] Wonkwang Univ, Sch Med, Dept Microbiol & Immunol, Iksan 570749, Chonbuk, South Korea

来源：

EXPERIMENTAL AND MOLECULAR MEDICINE | 2004年 / 36卷 / 03期

关键词：

asthma; hypersensitivity; polymorphism; rhinitis; Tim-3;

D O I：

10.1038/emm.2004.37

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The family of T-cell immunoglobulin domain and mucin domain (TIM) proteins is identified to be expressed on T cells. A member of Tim family, Tim-3 (T cell immunoglobulin mucin 3) is selectively expressed on the surface of differentiated Th1 cells. Tim-3 might have an important role in the induction of autoimmune diseases by regulating macrophage activation and interacts with Tim-3 ligand to regulate Th1 responses. To determine the variation sites in the coding and promoter region of human Tim-3 gene, we performed variation scanning by direct sequencing using the genomic DNA isolated from the patients with asthma or allergic rhinitis and healthy controls without asthma and allergic rhinitis. We identified four single nucleotide polymorphisms (SNPs) including one novel SNPs (-1541C >T) and two variation sites (-1292_-1289delTAAA and -1282_-1278dupTAAAA) in the coding and promoter region of human Tim-3 gene in both the patients and healthy groups.

引用

页码：274 / 278

页数：5