Copper-catalyzed conjugate addition on macrocyclic, cyclic, and acyclic enones with a chiral phosphoramidite ligand having a C2-symmetric amine moiety

被引：63

作者：

Choi, YH ^{[1
]}

Choi, JY ^{[1
]}

Yang, HY ^{[1
]}

Kim, YH ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem, Ctr Mol Design & Synth, Taejon 305701, South Korea

来源：

TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 08期

关键词：

D O I：

10.1016/S0957-4166(02)00206-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A binaphthol-based phosphoramidite ligand (4.2 mol%) having a C-2-symmetric chiral amine moiety was examined for enantioselective 1,4-additions of dialkylzinc reagents to various macrocyclic, cyclic, and acyclic enones catalyzed by copper triflate-toluene complex (2 mol%) to afford high enantiomeric excess (up to >95% ee). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：801 / 804

页数：4

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