Asymmetric conjugate addition of diethyl zinc to enones with chiral phosphorus ligands derived from TADDOL

被引：117

作者：

Alexakis, A ^{[1
]}

Vastra, J ^{[1
]}

Burton, J ^{[1
]}

Benhaim, C ^{[1
]}

Mangeney, P ^{[1
]}

机构：

[1] Univ Paris 06, Dept Chim Organ, UMR 7611 CNRS, F-75252 Paris 05, France

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 43期

关键词：

D O I：

10.1016/S0040-4039(98)01761-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric conjugate addition of diethyl zinc to cyclohexen-2-one, chalcone and benzalacetone was studied with 0.5% copper (II) triflate and 1% chiral phosphorus ligands derived from TADDOL. Among the several ligand tested, the cyclic phosphite obtained with 1S,2R phenylcyclohexanol gave up to 96% ee of conjugate adduct to cyclohexenone. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：7869 / 7872

页数：4

共 22 条

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