Peptide dendrimers based on polyproline helices

被引:110
作者
Crespo, L
Sanclimens, G
Montaner, B
Pérez-Tomás, R
Royo, M [1 ]
Pons, M
Albericio, F
Giralt, E
机构
[1] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Spain
[2] Univ Barcelona, Dept Biol Cellular & Anat Patol, Lhospitalet De Llobregat 08907, Spain
关键词
D O I
10.1021/ja020364m
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We present a new family of peptide dendrimers based on polyproline helices and cis-4-amino-L-proline as a branching unit. Dendrimers were synthesized by a convergent solid-phase peptide synthesis approach. The conformational transition between polyproline type I helix and polyproline type II helix was observed by circular dichroism in branched polyproline building blocks with more than 14 proline residues and in the resulting dendrimers. Both linear and dendritic polyprolines were found to be actively internalized by rat kidney cells. Preliminary results show that the antibiotic ciprofloxacin form complexes with branched polyproline chains in 99.5% propanol.
引用
收藏
页码:8876 / 8883
页数:8
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