The synthesis of 3-methyleneindol-2(3H)-ones related to mitomycins via 5-exo-dig aryl radical cyclisation

被引：39

作者：

Brunton, SA ^{[1
]}

Jones, K ^{[1
]}

机构：

[1] Kings Coll London, Dept Chem, London WC2R 2LS, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2000年 / 05期

关键词：

D O I：

10.1039/a907920c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of acetylenic amides from 2-bromoaniline and propiolic acids followed by their cyclisation via the derived aryl radical is presented. Silylation of the terminal end of the triple bond is shown to be required for successful cyclisation to 3-methyleneindol-2(3H)-ones. The exocyclic double bond can be epoxidised using m-chloroperoxybenzoic acid (MCPBA).

引用

页码：763 / 768

页数：6

共 16 条

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