Synthesis of 2′-deoxy-2′-[18F]fluoro-5-bromo-1-β-D-arabinofuranosyluracil ([18F]-FBAU) and 2′-deoxy-2′-[18F]fluoro-5-chloro-1-β-D-arabinofuranosyl-uracil ([18F]-FCAU), and their biological evaluation as markers for gene expression

被引：31

作者：

Alauddin, MM ^{[1
]}

Shahinian, A ^{[1
]}

Park, R ^{[1
]}

Tohme, M ^{[1
]}

Fissekis, JD ^{[1
]}

Conti, PS ^{[1
]}

机构：

[1] Univ So Calif, Dept Radiol, PET Imaging Sci Ctr, Los Angeles, CA 90033 USA

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2004年 / 31卷 / 04期

关键词：

FBAU; FCAU; FMAU; HSV-tk; PET; gene expression;

D O I：

10.1016/j.nucmedbio.2003.12.008

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

[F-18]-FBAU and [F-18]-FCAU have been synthesized and evaluated in vivo as markers for HSV1-tk gene expression. At 2 hours, uptake of [F-18]-FBAU and [F-18]-FCAU in HSV1-tk-positive tumors was 7.9-fold and 6.0-fold higher than the control tumors, respectively. Micro-PET images also showed very high uptake in HSV-tk tumors. Compared to [C-14]-FMAU, total uptake of [F-18]-FBAU and [F-18]-FCAU was similar in tk-positive cells, but the uptake ratio (tk+/wild) was higher. [F-18]-FCAU and [F-18]-FCAU appear to be potential PET imaging agents for gene expression. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：399 / 405

页数：7