Comparative genome analysis and molecular epidemiology of the reemerging porcine epidemic diarrhea virus strains isolated in Korea

被引：23

作者：

Choi, Jong-Chul ^{[1
]}

Lee, Kun-Kyu ^{[1
]}

Pi, Jae Ho ^{[2
]}

Park, Seung-Yong ^{[1
]}

Song, Chang-Seon ^{[1
]}

Choi, In-Soo ^{[1
]}

Lee, Joong-Bok ^{[1
]}

Lee, Dong-Hun ^{[1
]}

Lee, Sang-Won ^{[1
]}

机构：

[1] Konkuk Univ, Coll Vet Med, Seoul 143701, South Korea

[2] Sam Hwa Breeding Agri Inc, Hong Sung, Chung Nam, South Korea

来源：

INFECTION GENETICS AND EVOLUTION | 2014年 / 26卷

关键词：

Animal virus; Complete genome; Coronavirus; Phylogenetic analysis; Porcine epidemic diarrhea virus; TRANSMISSIBLE GASTROENTERITIS VIRUS;

D O I：

10.1016/j.meegid.2014.06.005

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Porcine epidemic diarrhea virus (PEDV), a member of the Coronaviridae family, is an enveloped, positive-sense, single-stranded RNA virus, which causes severe diarrhea and dehydration in suckling pigs. We detected three PEDV strains from ten small intestine samples from piglets with acute diarrhea and we determined the complete genome sequences of the reemerging Korean PEDV field isolates, except for the noncoding regions from both ends. The complete genome sequences of the strains were identical or almost identical (one synonymous single-nucleotide polymorphism (SNP) in the ORF1a/1b genomic sequence). Interestingly, comparative genome analysis of recent Korean PEDV isolates and other strains revealed that the complete genome sequences of recent Korean strains were almost identical (99.9%) to those of the US PEDV strains isolated in 2013. These results suggest that the three reemerging Korean strains are distinct from previous endemic Korean PEDV strains and has been recently introduced into Korea from oversea with high likelihood. (C) 2014 Elsevier B. V. All rights reserved.

引用

页码：348 / 351

页数：4

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