Iron-catalyzed three-component coupling of aldehyde, alkyne, and amine under neat conditions in air

被引：123

作者：

Chen, Wen-Wen ^{[1
]}

Nguyen, Rene V. ^{[1
]}

Li, Chao-Jun ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 24期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Iron-catalyzed; Three-component coupling; Aldehyde; Alkyne; Amine; C-H activation; Neat; In air; HIGHLY ENANTIOSELECTIVE SYNTHESIS; C-C BOND; ASYMMETRIC ONE-POT; TERMINAL ALKYNES; DIRECT-ADDITION; SULFIDE OXIDATION; H ACTIVATION; PROPARGYLAMINES; IMINES; SILVER;

D O I：

10.1016/j.tetlet.2009.03.182

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Various iron-salts (and complexes) and especially iron(III) chloride catalyzed the three-component coupling of aldehyde, alkyne, and amine to generate propargylic amines with high efficiency under neat conditions in air. The iron-catalyzed reaction is particularly effective for reactions involving aliphatic aldehydes. The reaction is not sensitive to and occurs smoothly in water and in air. No additional co-catalyst or activator is required. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2895 / 2898

页数：4

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