TFF-2 inhibits iNOS/NO in monocytes, and nitrated protein in healing colon after colitis

被引：29

作者：

Giraud, AS ^{[1
]}

Pereira, PM

Thim, L

Parker, LM

Judd, LM

机构：

[1] Univ Melbourne, Dept Med, Western Hosp, Footscray, Vic 3011, Australia

[2] Novo Nordisk AS, DK-2880 Bagsvaerd, Denmark

来源：

PEPTIDES | 2004年 / 25卷 / 05期

关键词：

trefoil peptide; nitric oxide; inducible nitric oxide synthase; colitis;

D O I：

10.1016/j.peptides.2004.01.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endogenous trefoil (TFF) peptides have reparative and anti-inflammatory actions in colitis because luminal application in vivo potently reduces inflammatory indices and accelerates healing. Since chronic production of NO via inducible nitric oxide synthase activity (iNOS) leads to tissue damage and inflammation, we tested whether TFF2 could inhibit NO production in a monocyte cell line in response to bacterial endotoxin, and in vivo by measuring inflammatory indices and nitrated protein expression in rat colon after colitis induction. We showed that TFF2 can inhibit iNOS and NO in monocytes and inflammatory compartment size in vivo, and conclude that trefoils can regulate monocyte NO-mediated inflammation in colitis. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：803 / 809

页数：7

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