Wnt signaling and osteoporosis

被引：146

作者：

Manolagas, Stavros C. ^{[1
,2
]}

机构：

[1] Univ Arkansas Med Sci, Div Endocrinol & Metab, Ctr Osteoporosis & Metab Bone Dis, Little Rock, AR 72205 USA

[2] Cent Arkansas Vet Healthcare Syst, Little Rock, AR USA

来源：

MATURITAS | 2014年 / 78卷 / 03期

关键词：

Osteoblasts; Osteoclasts; Osteocytes; RANKL; OPG; Bone therapies; INCREASES BONE-FORMATION; FORKHEAD-BOX-O; T-CELL-FACTOR; OXIDATIVE STRESS; BETA-CATENIN; DIFFERENTIATED OSTEOBLASTS; OSTEOCLAST DIFFERENTIATION; POSTMENOPAUSAL WOMEN; SCLEROSTIN ANTIBODY; MAINTENANCE;

D O I：

10.1016/j.maturitas.2014.04.013

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Major advances in understanding basic bone biology and the cellular and molecular mechanisms responsible for the development of osteoporosis, over the last 20 years, have dramatically altered the management of this disease. The purpose of this mini-review is to highlight the seminal role of Wnt signaling in bone homeostasis and disease and the emergence of novel osteoporosis therapies by targeting Wnt signaling with drugs. Published by Elsevier Ireland Ltd

引用

收藏

页码：233 / 237

页数：5

相关论文

共 42 条

[1]

Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by β-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT [J].

Almeida, M ;

Han, L ;

Bellido, T ;

Manolagas, SC ;

Kousteni, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (50) :41342-41351

[2]

Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids [J].

Almeida, Maria ;

Han, Li ;

Martin-Millan, Marta ;

Plotkin, Lilian I. ;

Stewart, Scott A. ;

Roberson, Paula K. ;

Kousteni, Stavroula ;

O'Brien, Charles A. ;

Bellido, Teresita ;

Parfitt, A. Michael ;

Weinstein, Robert S. ;

Jilka, Robert L. ;

Manolagas, Stavros C. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (37) :27285-27297

[3]

Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting β-catenin from T cell factor- to Forkhead box O-mediated transcription [J].

Almeida, Maria ;

Han, Li ;

Martin-Millan, Marta ;

O'Brien, Charles A. ;

Manolagas, Stavros C. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (37) :27298-27305

[4]

Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease [J].

Balemans, W ;

Patel, N ;

Ebeling, M ;

Van Hul, E ;

Wuyts, W ;

Lacza, C ;

Dioszegi, M ;

Dikkers, FG ;

Hildering, P ;

Willems, PJ ;

Verheij, JBGM ;

Lindpaintner, K ;

Vickery, B ;

Foernzler, D ;

Van Hul, W .

JOURNAL OF MEDICAL GENETICS, 2002, 39 (02) :91-97

[5]

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST) [J].

Balemans, W ;

Ebeling, M ;

Patel, N ;

Van Hul, E ;

Olson, P ;

Dioszegi, M ;

Lacza, C ;

Wuyts, W ;

Van den Ende, J ;

Willems, P ;

Paes-Alves, AF ;

Hill, S ;

Bueno, M ;

Ramos, FJ ;

Tacconi, P ;

Dikkers, FG ;

Stratakis, C ;

Lindpaintner, K ;

Vickery, B ;

Foernzler, D ;

Van Hul, W .

HUMAN MOLECULAR GENETICS, 2001, 10 (05) :537-543

[6]

WNT signaling in bone homeostasis and disease: from human mutations to treatments [J].

Baron, Roland ;

Kneissel, Michaela .

NATURE MEDICINE, 2013, 19 (02) :179-192

[7]

Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation [J].

Bennett, Christina N. ;

Ouyang, Hongjiao ;

Ma, Yanfei L. ;

Zeng, Qingqiang ;

Gerin, Isabelle ;

Sousa, Kyle M. ;

Lane, Timothy F. ;

Krishnan, Venkatesh ;

Hankenson, Kurt D. ;

MacDougald, Ormond A. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 (12) :1924-1932

[8]

The Amazing Osteocyte [J].

Bonewald, Lynda F. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2011, 26 (02) :229-238

[9]

High bone density due to a mutation in LDL-receptor-related protein 5 [J].

Boyden, LM ;

Mao, JH ;

Belsky, J ;

Mitzner, L ;

Farhi, A ;

Mitnick, MA ;

Wu, DQ ;

Insogna, K ;

Lifton, RP .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (20) :1513-1521

[10]

Osteoclast differentiation and activation [J].

Boyle, WJ ;

Simonet, WS ;

Lacey, DL .

NATURE, 2003, 423 (6937) :337-342

← 1 2 3 4 5 →