One-pot multi-substrate enantioselective conjugate addition of diethylzinc to nitroalkenes

被引：91

作者：

Duursma, A ^{[1
]}

Minnaard, AJ ^{[1
]}

Feringa, BL ^{[1
]}

机构：

[1] Univ Groningen, Dept Organ & Mol Inorgan Chem, Stratingh Inst, NL-9747 AG Groningen, Netherlands

来源：

TETRAHEDRON | 2002年 / 58卷 / 29期

关键词：

combinatorial chemistry; asymmetric catalysis; phosphoramidities; copper; conjugate addition;

D O I：

10.1016/S0040-4020(02)00574-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A multi-substrate approach is used in the copper-phosphoramidite catalyzed enantioselective conjugate addition of diethylzinc to nitroalkenes, using up to nine different nitroalkenes in a one pot procedure. The 18 products (9 times 2 enantiomers of nine different nitroalkanes) can be analyzed by chiral CG in a single run since on overlap in the peaks is observed. The obtained enantioselectivities are amongst the highest reported so far for the catalytic 1,4-addition of dialkylzinc reagents to nitroalkenes. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：5773 / 5778

页数：6

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