Characterization of pABVA01, a Plasmid Encoding the OXA-24 Carbapenemase from Italian Isolates of Acinetobacter baumannii

被引：85

作者：

D'Andrea, Marco Maria ^{[1
]}

Giani, Tommaso ^{[1
]}

D'Arezzo, Silvia ^{[3
]}

Capone, Alessandro ^{[3
]}

Petrosillo, Nicola ^{[3
]}

Visca, Paolo ^{[3
,4
]}

Luzzaro, Francesco ^{[5
]}

Rossolini, Gian Maria ^{[1
,2
]}

机构：

[1] Univ Siena, Dipartimento Biol Mol, Sez Microbiol, I-53100 Siena, Italy

[2] Azienda Osped Univ Senese, Dipartimento Servizi, Unita Operat Microbiol & Virol, I-53100 Siena, Italy

[3] Ist Nazl Malattie Infett Lazzaro Spallanzani, I-00149 Rome, Italy

[4] Univ Roma Tre, Dipartimento Biol, I-00146 Rome, Italy

[5] Univ Insubria, Osped Circolo, Microbiol Lab, I-21100 Varese, Italy

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 08期

关键词：

METALLO-BETA-LACTAMASE; FIELD GEL-ELECTROPHORESIS; CLINICAL ISOLATE; GENE; RESISTANCE; OXACILLINASE; STRAINS; OUTBREAK; INTEGRON; GENOME;

D O I：

10.1128/AAC.00178-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two epidemiologically unrelated carbapenem-resistant Acinetobacter baumannii isolates were investigated as representatives of the first Italian isolates producing the OXA-24 carbapenemase. Both isolates were of European clonal lineage II and carried an identical OXA-24-encoding plasmid, named pABVA01. Comparative analysis revealed that in pABVA01, bla(OXA-24) was part of a DNA module flanked by conserved inverted repeats homologous to XerC/XerD binding sites, which in other Acinetobacter plasmids flank different DNA modules, suggesting mobilization by a novel site-specific recombination mechanism.

引用

页码：3528 / 3533

页数：6

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