Cysteine cathepsins: multifunctional enzymes in cancer

被引：988

作者：

Mohamed, Mona Mostafa

Sloane, Bonnie F. ^{[1
]}

机构：

[1] Wayne State Univ, Sch Med, Dept Pharmacol, Detroit, MI 48201 USA

[2] Cairo Univ, Fac Sci, Dept Zool, Cairo, Egypt

[3] Wayne State Univ, Sch Med, Barbara Ann Karmanos Canc Inst, Detroit, MI USA

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 10期

关键词：

D O I：

10.1038/nrc1949

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cysteine cathepsins are highly upregulated in a wide variety of cancers by mechanisms ranging from gene amplification to post-transcriptional modification. Their localization within intracellular lysosomes often changes during neoplastic progression, resulting in secretion of both inactive and active forms and association with binding partners on the tumour cell surface. Secreted, cell-surface and intracellular cysteine cathepsins function in proteolytic pathways that increase neoplastic progression. Direct proof for causal roles in tumour growth, migration, invasion, angiogenesis and metastasis has been shown by downregulating or ablating the expression of individual cysteine cathepsins in tumour cells and in transgenic mouse models of human cancer.

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页码：764 / 775

页数：12

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