Cysteine cathepsins are highly upregulated in a wide variety of cancers by mechanisms ranging from gene amplification to post-transcriptional modification. Their localization within intracellular lysosomes often changes during neoplastic progression, resulting in secretion of both inactive and active forms and association with binding partners on the tumour cell surface. Secreted, cell-surface and intracellular cysteine cathepsins function in proteolytic pathways that increase neoplastic progression. Direct proof for causal roles in tumour growth, migration, invasion, angiogenesis and metastasis has been shown by downregulating or ablating the expression of individual cysteine cathepsins in tumour cells and in transgenic mouse models of human cancer.
机构:Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, Brazil
Nascimento, FD
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Rizzi, CCA
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机构:Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, Brazil
Rizzi, CCA
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Nantes, IL
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机构:Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, Brazil
Nantes, IL
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Stefe, L
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机构:Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, Brazil
Stefe, L
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Turk, B
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机构:Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, Brazil
Turk, B
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Carmona, AK
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机构:Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, Brazil
Carmona, AK
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Nader, HB
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机构:Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, Brazil
Nader, HB
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Juliano, L
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机构:Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, Brazil
Juliano, L
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Tersariol, ILS
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Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, BrazilUniv Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, Brazil
机构:Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, Brazil
Nascimento, FD
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Rizzi, CCA
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机构:Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, Brazil
Rizzi, CCA
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Nantes, IL
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机构:Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, Brazil
Nantes, IL
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Stefe, L
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机构:Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, Brazil
Stefe, L
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Turk, B
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机构:Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, Brazil
Turk, B
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Carmona, AK
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机构:Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, Brazil
Carmona, AK
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Nader, HB
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机构:Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, Brazil
Nader, HB
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Juliano, L
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机构:Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, Brazil
Juliano, L
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Tersariol, ILS
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Univ Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, BrazilUniv Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, Sao Paulo, Brazil