Signal transduction: Prelude to an anniversary for the RAS oncogene

被引:34
作者
Downward, Julian [1 ]
机构
[1] Canc Res UK London Res Inst, Signal Transduct Lab, London WC2A 3PX, England
关键词
D O I
10.1126/science.1134727
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A recent conference focused on the role of RAS in cancer, nearly a quarter of a century after its identification as the first human oncogene.
引用
收藏
页码:433 / 434
页数:2
相关论文
共 11 条
[1]   Germline mutations in HRAS proto-oncogene cause Costello syndrome [J].
Aoki, Y ;
Niihori, T ;
Kawame, H ;
Kurosawa, K ;
Filocamo, M ;
Kato, K ;
Suzuki, Y ;
Kure, S ;
Matsubara, Y .
NATURE GENETICS, 2005, 37 (10) :1038-1040
[2]   Live-cell imaging of endogenous Ras-GTP illustrates predominant Ras activation at the plasma membrane [J].
Augsten, M ;
Pusch, R ;
Biskup, C ;
Rennert, K ;
Wittig, U ;
Beyer, K ;
Blume, A ;
Wetzker, R ;
Friedrich, K ;
Rubio, I .
EMBO REPORTS, 2006, 7 (01) :46-51
[3]   Targeting ras signalling pathways in cancer therapy [J].
Downward, J .
NATURE REVIEWS CANCER, 2003, 3 (01) :11-22
[4]   Timeline - RAS oncogenes: the first 30 years [J].
Malumbres, M ;
Barbacid, M .
NATURE REVIEWS CANCER, 2003, 3 (06) :459-465
[5]   Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation:: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation [J].
Matallanas, D ;
Sanz-Moreno, V ;
Arozarena, I ;
Calvo, F ;
Agudo-Ibáñez, L ;
Santos, E ;
Berciano, MT ;
Crespo, P .
MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (01) :100-116
[6]   Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome [J].
Niihori, T ;
Aoki, Y ;
Narumi, Y ;
Neri, G ;
Cavé, H ;
Verloes, A ;
Okamoto, N ;
Hennekam, RCM ;
Gillessen-Kaesbach, G ;
Wieczorek, D ;
Kavamura, MI ;
Kurosawa, K ;
Ohashi, H ;
Wilson, L ;
Heron, D ;
Bonneau, D ;
Corona, G ;
Kaname, T ;
Naritomi, K ;
Baumann, C ;
Matsumoto, N ;
Kato, K ;
Kure, S ;
Matsubara, Y .
NATURE GENETICS, 2006, 38 (03) :294-296
[7]   H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton [J].
Plowman, SJ ;
Muncke, C ;
Parton, RG ;
Hancock, JF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (43) :15500-15505
[8]   Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome [J].
Rodriguez-Viciana, P ;
Tetsu, O ;
Tidyman, WE ;
Estep, AL ;
Conger, BA ;
Cruz, MS ;
McCormick, F ;
Rauen, KA .
SCIENCE, 2006, 311 (5765) :1287-1290
[9]   Germline KRAS mutations cause Noonan syndrome [J].
Schubbert, S ;
Zenker, M ;
Rowe, SL ;
Böll, SB ;
Klein, C ;
Bollag, G ;
van der Burgt, I ;
Musante, L ;
Kalscheuer, V ;
Wehner, LE ;
Nguyen, H ;
West, B ;
Zhang, KYJ ;
Sistermans, E ;
Rauch, A ;
Niemeyer, CM ;
Shannon, K ;
Kratz, CP .
NATURE GENETICS, 2006, 38 (03) :331-336
[10]   Somatic alterations in the human cancer genome [J].
Weir, B ;
Zhao, XJ ;
Meyerson, M .
CANCER CELL, 2004, 6 (05) :433-438