National survey of invasive pneumococcal diseases in Taiwan under partial PCV7 vaccination in 2007: Emergence of serotype 19A with high invasive potential

被引：86

作者：

Hsieh, Yu-Chia ^{[1
]}

Lin, Pen-Yi ^{[1
]}

Chiu, Cheng-Hsun ^{[1
]}

Huang, Yhu-Chering ^{[1
]}

Chang, Kuang-Yi ^{[2
,3
,4
]}

Liao, Chun-Hsing ^{[5
]}

Chiu, Nan-Chang ^{[6
]}

Chuang, Yin-Ching ^{[7
]}

Chen, Po-Yen ^{[8
]}

Chang, Shan-Chwen ^{[9
]}

Liu, Jien-Wei ^{[10
]}

Yen, Muh-Yong ^{[11
]}

Wang, Jen-Hsien ^{[12
]}

Liu, Cheng-Yi ^{[13
]}

Lin, Tzou-Yien ^{[1
]}

机构：

[1] Chang Gung Univ, Dept Pediat, Chang Gung Childrens Hosp, Chang Gung Mem Hosp,Coll Med, Tao Yuan, Taiwan

[2] Natl Taiwan Univ, Div Biostat, Coll Publ Hlth, Taipei, Taiwan

[3] Taipei Vet Gen Hosp, Dept Anesthesiol, Taipei, Taiwan

[4] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

[5] Far Eastern Mem Hosp, Dept Internal Med, Taipei, Taiwan

[6] Mackay Mem Hosp, Dept Pediat, Taipei, Taiwan

[7] Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan

[8] Taichung Vet Gen Hosp, Dept Pediat, Taichung, Taiwan

[9] Natl Taiwan Univ Hosp, Dept Internal Med, Div Infect Dis, Taipei 100, Taiwan

[10] Chang Gung Mem Hosp, Div Infect Dis, Dept Internal Med, Kaohsiung Med Ctr, Kaohsiung, Taiwan

[11] Taipei City Hosp, Dept Internal Med, Taipei, Taiwan

[12] China Med Univ Hosp, Infect Dis Sect, Dept Med, Taichung, Taiwan

[13] Taipei Vet Gen Hosp, Dept Internal Med, Taipei, Taiwan

来源：

VACCINE | 2009年 / 27卷 / 40期

关键词：

Invasive pneumococcal diseases; Serotype; 19A; Invasive potential; RESISTANT STREPTOCOCCUS-PNEUMONIAE; ACUTE OTITIS-MEDIA; CONJUGATE VACCINE; UNITED-STATES; ANTIMICROBIAL RESISTANCE; MACROLIDE RESISTANCE; MAJOR CLONES; CHILDREN; EPIDEMIOLOGY; SURVEILLANCE;

D O I：

10.1016/j.vaccine.2009.06.091

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We conducted an active, population-based laboratory surveillance study to evaluate the epidemiologic features of invasive pneumococcal disease (IPD) in Taiwan. Concurrently, nasopharyngeal colonization of Streptococcus pneumoniae was evaluated among 1128 healthy children aged <= 5 years. The overall incidence was highest among children aged 2-4 years (15.6/100,000). Serotype 19A. which had never been reported in Taiwan previously, caused a substantial fraction of the invasive diseases (OR, 9.6: 95% Cl, 3.1-29.4) among children aged 2-4 years. Comparing serotype distributions of the isolates from nasopharyngeal colonization among children aged <= 5 years, serotypes 14 (OR, 17.3; 95% CI, 5.2-57.9) and 19A (OR, 14.9; 95% CI, 1.9-117) had the highest invasive potential. The study found that serotype 19A expanded in Taiwan, a country with a low 7-valent conjugate pneumococcal vaccine coverage. The 7-valent conjugate pneumococcal vaccines covered 73% of cases in children aged between 2 and 4 years, and 64.7% of cases in children aged <2 years. Among patients aged >= 65 years, the 23-valent pneumococcal polysaccharide vaccine covered 70.4% of cases. In the future, a broader pneumococcal vaccine is needed. (C) 2009 Published by Elsevier Ltd.

引用

页码：5513 / 5518

页数：6

共 32 条

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