Expression of MHC class I heavy chain and β2-microglobulin in rat brainstem motoneurons and nigral dopaminergic neurons

被引：68

作者：

Lindå, H

Hammarberg, H

Piehl, F

Khademi, M

Olsson, T

机构：

[1] Huddinge Hosp, Karolinska Inst, Dept Neurol, S-14186 Huddinge, Sweden

[2] Karolinska Hosp, Dept Neurosci, S-10401 Stockholm, Sweden

[3] Karolinska Hosp, Dept Mol Med, S-17176 Stockholm, Sweden

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1999年 / 101卷 / 01期

关键词：

brainstem motoneurons; dopaminergic neurons; MHC class I; beta; 2-microglobulin; interferon-gamma receptor;

D O I：

10.1016/S0165-5728(99)00135-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We demonstrate here that motoneurons and nigral dopaminergic neurons in the brainstem of the adult rat, with the exception of motoneurons innervating ocular muscles, display high levels of both MHC class I heavy chain and beta 2-microglobulin mRNAs. These neurons also display interferon-gamma receptor mRNA. We find it striking that these particular neurons are those which are vulnerable to neurodegeneration in diseases such as Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：76 / 86

页数：11

共 41 条

[11] SENSITIVE MESSENGER-RNA DETECTION USING UNFIXED TISSUE - COMBINED RADIOACTIVE AND NONRADIOACTIVE INSITU HYBRIDIZATION HISTOCHEMISTRY [J].