A Ph-negative chronic myeloid leukemia with a complex BCR/ABL rearrangement and a t(6;9)(p21;q34.1)

被引：14

作者：

Todoric-Zivanovic, B

Marisavljevic, D

Surace, C

Cemerikic, V

Markovic, O

Krtolica, K

Tatomirovic, Z

Cikota, B

Magic, Z

Rocchi, M

机构：

[1] Mil Med Acad, Belgrade 11000, Serbia Monteneg

[2] Med Training Ctr Bezanijska Kosa, Belgrade 11000, Serbia Monteneg

[3] Histolab, Belgrade 11000, Serbia Monteneg

[4] Inst Nucl Sci Vinca, Belgrade 11000, Serbia Monteneg

[5] Univ Bari, Dipartimento Anat Pathol & Genet, Sezione Genet, I-70126 Bari, Italy

来源：

CANCER GENETICS AND CYTOGENETICS | 2006年 / 166卷 / 02期

关键词：

D O I：

10.1016/j.cancergencyto.2005.11.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chronic myeloid leukemia (CML) is a clonal malignant disorder of a pluripotent hematopoetic stem cell characterized by the presence of the Philadelphia (Ph) chromosome in more than 90% of patients. Cryptic or "masked" BCR/ABL gene rearrangements may be found in cases with a normal karyotype and in cases with the complex karyotype, in which typical t(9;22) is not visible at the microscopic level. Those rearrangements can now be detected by fluorescence in situ hybridization. Here, we report on a novel and complex Ph chromosome-negative CML case with a t(6;9) (p21;q34.1) in which the BCR/ABL fusion gene is located at 6p21. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：180 / 185

页数：6

共 20 条

[1] REVERSED BCR/ABL REARRANGEMENT DETECTED BY FISH IN PHILADELPHIA NEGATIVE CHRONIC MYELOCYTIC-LEUKEMIA [J].