PTP1-B inhibitors from Saussrurea Lappa

被引：37

作者：

Li, S.

An, T. -Y

Li, J.

Shen, Q.

Lou, F-C.

Hu, L. -H. ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Biol Sci, Shanghai Inst Mat Med, Chinese Natl Ctr Drug Screening, Shanghai 201203, Peoples R China

[2] China Pharmaceut Univ, Dept Phytochem, Nanjing 210038, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2006年 / 8卷 / 03期

关键词：

Saussurea lappa; PTP1B inhibitors; 1,5-dihydroxypinoresinol-4 '-O-beta-D-glucopyranoside;

D O I：

10.1080/10286020412331286434

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

A new lignan glycoside, named 1,5-dihydroxypinoresinol-4'-O-beta-D-glueopyranoside (1), has been isolated from the EtOH extract of the roots of Saussurea lappa, together with twenty known compounds: (+)-1-hydroxypinoresinol-1-O-beta-D-glucopyranoside (2), fraxiresinol-4'-O-beta-D-glucopyranoside (3), (-)-olivil-4 ''-O-beta-D-gucopyranoside (4), 4-allyl-2,6-dimethoxybenzene-1-O-beta-D-glucopyranoside, syringin, costunolide-15-O-beta-D-glucopyranoside, chlorogenic acid, aloe-emodin-8-O-beta-D-glucopyranoside (5), rhein-8-O-beta-D-glucopyranoside (6), chrysophanol (7), emodin, dehydrocostus lactone, costunolide, P-costic acid, reynosin, arbusculin A, a-cyclocostunolide, P-cyclocostunolide, santamarine and magnolialide. Three anthraquinones (5-7) showed moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTPIB) in vitro.

引用

页码：281 / 286

页数：6

共 19 条

[1]

Natural PTP1B inhibitors from Broussonetia papyrifera [J].