MicroRNA: Important Player in the Pathobiology of Multiple Myeloma

被引：53

作者：

Bi, Chonglei ^{[1
,2
]}

Chng, Wee Joo ^{[1
,2
,3
]}

机构：

[1] Canc Sci Inst Singapore, Ctr Translat Med, Singapore 117599, Singapore

[2] Yong Loo Lin Sch Med, Singapore 119228, Singapore

[3] Natl Univ Hlth Syst, Natl Univ Canc Inst, Dept Hematol Oncol, Singapore 119228, Singapore

来源：

BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷

关键词：

GENE-EXPRESSION PROFILES; PLASMA-CELL DYSCRASIAS; MONOCLONAL GAMMOPATHY; MOLECULAR CLASSIFICATION; DOWN-REGULATION; IN-VITRO; EPIGENETIC INACTIVATION; IGH TRANSLOCATIONS; KAPPA-B; UNDETERMINED SIGNIFICANCE;

D O I：

10.1155/2014/521586

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Recent studies have revealed a pivotal role played by a class of small, noncoding RNAs, microRNA (miRNA), in multiple myeloma (MM), a plasma cell (PC) malignancy causing significant morbidity and mortality. Deregulated miRNA expression in patient's PCs and plasma has been associated with tumor progression, molecular subtypes, clinical staging, prognosis, and drug response in MM. A number of important oncogenic and tumor suppressor miRNAs have been discovered to regulate important genes and pathways such as p53 and IL6-JAK-STAT signaling. miRNAs may also form complex regulatory circuitry with genetic and epigenetic machineries, the deregulation of which could lead to malignant transformation and progression. The translational potential of miRNAs in the clinic is being increasingly recognized that they could represent novel biomarkers and therapeutic targets. This review comprehensively summarizes current progress in delineating the roles of miRNAs in MM pathobiology and management.

引用

页数：12

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