The role of kallikrein-related peptidases in prostate cancer: potential involvement in an epithelial to mesenchymal transition

被引：29

作者：

Whitbread, Astrid K.

Veveris-Lowe, Tara L.

Lawrence, Mitchell G.

Nicol, David L.

Clements, Judith A. ^{[1
]}

机构：

[1] Queensland Univ Technol, Sch Life Sci, Hormone Dependent Canc Program, Brisbane, Qld 4000, Australia

[2] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4000, Australia

[3] Princess Alexandra Hosp, Dept Urol, Brisbane, Qld 4102, Australia

来源：

BIOLOGICAL CHEMISTRY | 2006年 / 387卷 / 06期

关键词：

E-cadherin; EMT; KLK4; migration; prostate cancer; PSA;

D O I：

10.1515/BC.2006.089

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several members of the kallikrein-related peptidase family of serine proteases have proteolytic activities that may affect cancer progression; however, the in vivo significance of these activities remains uncertain. We have demonstrated that expression of PSA or KLK4, but not KLK2, in PC-3 prostate cancer cells changed the cellular morphology from epithelial to spindle-shaped, markedly reduced E-cadherin expression, increased vimentin expression and increased cellular migration. These changes are indicative of an epithelial to mesenchymal transition (EMT), a process important in embryonic development and cancer progression. The potential novel role of kallikrein-related peptidases in this process is the focus of this brief review.

引用

页码：707 / 714

页数：8

共 108 条

[1] Epithelial mesenchymal interactions in cancer and development [J].

Arias, AM .

CELL, 2001, 105 (04) :425-431

[2]

Australian Institute of Health and Welfare (AIHW), 2004, AUSTR HLTH 2004

[3] Glycogen synthase kinase-3 is an endogenous inhibitor of snail transcription: implications for the epithelial-mesenchymal transition [J].

Bachelder, RE ;

Yoon, SO ;

Franci, C ;

de Herreros, AG ;

Mercurio, AM .

JOURNAL OF CELL BIOLOGY, 2005, 168 (01) :29-33

[4] Transcriptional activation of integrin β6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma [J].

Bates, RC ;

Bellovin, DI ;

Brown, C ;

Maynard, E ;

Wu, BY ;

Kawakatsu, H ;

Sheppard, D ;

Oettgen, P ;

Mercurio, AM .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (02) :339-347

[5] The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells [J].

Batlle, E ;

Sancho, E ;

Franci, C ;

Domínguez, D ;

Monfar, M ;

Baulida, J ;

de Herreros, AG .

NATURE CELL BIOLOGY, 2000, 2 (02) :84-89

[6] Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system [J].

Bernett, MJ ;

Blaber, SI ;

Scarisbrick, IA ;

Dhanarajana, P ;

Thomspon, SM ;

Blaber, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (27) :24562-24570

[7] CADHERIN EXPRESSION IN CARCINOMAS - ROLE IN THE FORMATION OF CELL-JUNCTIONS AND THE PREVENTION OF INVASIVENESS [J].

BIRCHMEIER, W ;

BEHRENS, J .

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 1994, 1198 (01) :11-26

[8] The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions:: a comparison with Snail and E47 repressors [J].

Bolós, V ;

Peinado, H ;

Pérez-Moreno, MA ;

Fraga, MF ;

Esteller, M ;

Cano, A .

JOURNAL OF CELL SCIENCE, 2003, 116 (03) :499-511

[9] The emerging roles of human tissue kallikreins in cancer [J].

Borgoño, CA ;

Diamandis, EP .

NATURE REVIEWS CANCER, 2004, 4 (11) :876-890

[10]

Borgoño CA, 2003, CANCER RES, V63, P9032

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