The role of kallikrein-related peptidases in prostate cancer: potential involvement in an epithelial to mesenchymal transition

被引：29

作者：

Whitbread, Astrid K.

Veveris-Lowe, Tara L.

Lawrence, Mitchell G.

Nicol, David L.

Clements, Judith A. ^{[1
]}

机构：

[1] Queensland Univ Technol, Sch Life Sci, Hormone Dependent Canc Program, Brisbane, Qld 4000, Australia

[2] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4000, Australia

[3] Princess Alexandra Hosp, Dept Urol, Brisbane, Qld 4102, Australia

来源：

BIOLOGICAL CHEMISTRY | 2006年 / 387卷 / 06期

关键词：

E-cadherin; EMT; KLK4; migration; prostate cancer; PSA;

D O I：

10.1515/BC.2006.089

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several members of the kallikrein-related peptidase family of serine proteases have proteolytic activities that may affect cancer progression; however, the in vivo significance of these activities remains uncertain. We have demonstrated that expression of PSA or KLK4, but not KLK2, in PC-3 prostate cancer cells changed the cellular morphology from epithelial to spindle-shaped, markedly reduced E-cadherin expression, increased vimentin expression and increased cellular migration. These changes are indicative of an epithelial to mesenchymal transition (EMT), a process important in embryonic development and cancer progression. The potential novel role of kallikrein-related peptidases in this process is the focus of this brief review.

引用

页码：707 / 714

页数：8

共 108 条

[51] Human kallikrein 8: Immunoassay development and identification in tissue extracts and biological fluids [J].

Kishi, T ;

Grass, L ;

Soosaipillai, A ;

Shimizu-Okabe, C ;

Diamandis, EP .

CLINICAL CHEMISTRY, 2003, 49 (01) :87-96

[52] E-cadherin expression and PSA secretion in human prostate epithelial cells [J].

Krill, D ;

Thomas, A ;

Wu, SP ;

Dhir, R ;

Becich, MJ .

UROLOGICAL RESEARCH, 2001, 29 (04) :287-292

[53]

Kumar A, 1997, CANCER RES, V57, P3111

[54] Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target [J].

Kwok, WK ;

Ling, MT ;

Lee, TW ;

Lau, TCM ;

Zhou, C ;

Zhang, XM ;

Chua, CW ;

Chan, KW ;

Chan, FL ;

Glackin, C ;

Wong, YC ;

Wang, XH .

CANCER RESEARCH, 2005, 65 (12) :5153-5162

[55] SEMINAL VESICLE-SECRETED PROTEINS AND THEIR REACTIONS DURING GELATION AND LIQUEFACTION OF HUMAN-SEMEN [J].

LILJA, H ;

OLDBRING, J ;

RANNEVIK, G ;

LAURELL, CB .

JOURNAL OF CLINICAL INVESTIGATION, 1987, 80 (02) :281-285

[56] A KALLIKREIN-LIKE SERINE PROTEASE IN PROSTATIC FLUID CLEAVES THE PREDOMINANT SEMINAL-VESICLE PROTEIN [J].

LILJA, H .

JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (05) :1899-1903

[57]

LILJA H, 1989, J BIOL CHEM, V264, P1894

[58] Activation of the zymogen form of prostate-specific antigen by human glandular kallikrein 2 [J].

Lovgren, J ;

Rajakoski, K ;

Karp, M ;

Lundwall, A ;

Lilja, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 238 (02) :549-555

[59] Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion [J].

Lu, ZM ;

Ghosh, S ;

Wang, ZY ;

Hunter, T .

CANCER CELL, 2003, 4 (06) :499-515

[60]

Luo J, 1999, CANCER RES, V59, P3552

← 1 2 3 4 5 6 7 8 9 10 →